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. 2021 Jul 31;22(15):8248. doi: 10.3390/ijms22158248

Figure 3.

Figure 3

Schematic cartoon summarizing hypothetical models of Netrin-1 signaling that could promote expression of C-MYC. (A) Interaction of Netrin-1 with its receptor UNC5A may trigger the phosphorylation of NF-κB and the activation of the expression of C-MYC [10]. (B) Interaction of Netrin-1 with its receptors NEO-1 and UNC5B could promote the phosphorylation of Gsk3α/β and the stabilization of β-catenin, which in turn could trigger the expression of C-MYC [84]. (C) Interaction of Netrin-1 with its receptor NEO-1 could promote the activation of an Integrin heterodimer, formed by α and β1 subunits, and trigger the expression of C-MYC through regulation of the MAPK/SRC axis. STAT3 and ERK 1/2 may promote the induction of C-MYC expression by acting as transcription factors in the promoting region of the gene [80].