Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 6;22:600. doi: 10.1186/s12864-021-07898-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 3 — Transcription-coupled repair in mouse lemur and human fibroblasts. Average profiles of CPD XR-seq (top) and (6–4)PP XR-seq (bottom) over 5277 and 3366 annotated genes are plotted for human (left) and mouse lemur (right), respectively. Transcription start sites (TSS) and transcription end sites (TES) were retrieved from GTF (Gene Transfer Format) files for the two genomes. Transcribed (red) and nontranscribed (blue) strand repair are shown in the downstream and upstream of TSS and TES, respectively. 10 kb upstream and downstream of TSS and TES were divided into 100 bp windows. XR-seq reads aligned to each bin were normalized to RPKM (reads per kilobase per million mapped reads). The XR-seq RPKM values were normalized by the shuffled RPKM values derived by mapped reads aligned to random genomic sites. Only replicate 1 is shown. TS/NTS median values for TSS downstream for CPD are 1.76 and 2.31 for human and mouse lemur, respectively