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. 2021 Aug 6;19:231. doi: 10.1186/s12957-021-02340-0

Table 3.

Incidence rate and severity of adverse events in maintenance therapy

Adverse events	Grade	Cases (incidence rate %)
Leukopenia	Grade 1–2	27 (38.03%)
Leukopenia	Grade 3–4	19 (26.76%)
Neutropenia	Grade 1–2	23 (32.39%)
Neutropenia	Grade 3–4	12 (16.90%)
Thrombocytopenia	Grade 1–2	17 (23.94%)
Thrombocytopenia	Grade 3–4	7 (9.86%)
Anemia	Grade 1–2	31 (43.66%)
Anemia	Grade 3–4	12 (16.90%)
Nausea	Grade 1–2	20 (28.17%)
Nausea	Grade 3–4	3 (4.23%)
Vomiting	Grade 1–2	18 (25.35%)
Vomiting	Grade 3–4	2 (2.82%)
Diarrhea	Grade 1–2	7 (9.86%)
Diarrhea	Grade 3–4	2 (2.82%)
Neurotoxicity	Grade 1–2	4 (5.63%)
Neurotoxicity	Grade 3–4	1 (1.41%)
Transaminase elevation	Grade 1–2	13 (18.31%)
Transaminase elevation	Grade 3–4	2 (2.82%)
Renal toxicity	Grade 1–2	9 (12.67%)
Renal toxicity	Grade 3–4	3 (4.23%)
Weakness	Grade 1–2	33 (46.47%)
Weakness	Grade 3–4	5 (7.04%)
Rash	Grade 1–2	9 (12.67%)
Rash	Grade 3–4	3 (4.23%)
Myalgia	Grade 1–2	3 (4.23%)
Arrhythmia	Grade 1–2	2 (2.82%)