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. 2021 Aug 6;19:234. doi: 10.1186/s12951-021-00967-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Pregnancy exposure to TiO₂NPs did not affect body weight, litter size and sex ratio of offspring. A Effects of TiO₂NPs on the body weight of pregnant mice. B Effects of TiO₂NPs on the body weight of offspring from postnatal day (PD) 1 to PD49. C Effects of TiO₂NPs on the little size. D Effects of TiO₂NPs on the sex ratio (female/male) of offspring. Data were presented as mean ± S.E.M. Statistical analysis was performed by using independent student t test or Mann–Whitney U test