Fig. 6.

Pregnancy exposure to TiO₂NPs inhibited the locomotor activity of offspring at PD49 but not occurred at PD21. After pregnancy exposure to TiO₂NPs, the locomotor activity of offspring was evaluated by open field test at postnatal day (PD) 21 and PD49. A Effects of TiO₂NPs on the total distance. B Effects of TiO₂NPs on the central square duration. C Effects of TiO₂NPs on the distance moved in center. D The representative track maps in the open field test. Data were presented as mean ± S.E.M. Statistical analysis was performed by using repeated-measure ANOVA or independent student t test or Mann–Whitney U test