Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 7;19:336. doi: 10.1186/s12967-021-02998-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 4 — Significant dysregulation of canonical pathways observed through changes in expression of the mRNA targets of differentially expressed miRNAs. Experimentally verified and differentially expressed mRNA targets of differentially expressed miRNAs were analyzed using IPA to predict effects of miRNA-mRNA pairs on canonical pathways. A Heatmap displays canonical pathways that were predicted to be significantly dysregulated (B-H p-value < 0.01 across all doses) based upon differentially expressed mRNA targets. A positive z-score indicates predicted activation of the pathway based on gene expression and a negative z-score indicates predicted deactivation of the pathway based on gene expression. Pathways are hierarchically clustered by z-score. B Fold changes of inversely correlated miRNA-mRNA target pairs with involvement in the significantly dysregulated pathways. Three miRNAs had two mRNA targets each that were inversely correlated across all doses and significant in at least one condition