KEY RESOURCES TABLE
| REAGENT or RESOURCE | SOURCE | IDENTIFIER |
|---|---|---|
| Bacterial and Virus Strains | ||
| Escherichia coli BW25113 | CGSC | 7636 |
| Staphylococcus aureus USA 300 | ATCC | 25904 |
| Klebsiella pneumoniae ATCC 700721 | ATCC | 700721 |
| Acinetobacter baumannii ATCC 17978 | ATCC | 17978 |
| Pseudomonas aeruginosa PA01 | ATCC | 47085 |
| Clostridioides difficile 630 | ATCC | BAA-1382 |
| Mycobacterium tuberculosis H37Rv | ATCC | 25618 |
| Antibiotic-resistant isolates from CDC | CDC AR Isolate Bank | See Table S3 for unique identifiers |
| Chemicals, Peptides, and Recombinant Proteins | ||
| SU3327 (halicin) | TCI chemicals | A2940 |
| ZINC000013517522 | Vitas-M | STL439768 |
| ZINC000006719085 | Vitas-M | STK708267 |
| ZINC000101675810 | Vitas-M | STK940888 |
| ZINC000101676256 | Vitas-M | STK929481 |
| ZINC000018090096 | Specs | AP-216/15652011 |
| ZINC000169457956 | Specs | AP-216/15652003 |
| ZINC000004481415 | IBScreen | STOCK1S-22001 |
| ZINC000019771150 | ChemBridge | 5773027 |
| ZINC000001387673 | ChemBridge | 5253687 |
| ZINC000005510605 | TimTec | ST50999405 |
| ZINC000022865640 | TimTec | ST50990898 |
| ZINC000015134557 | TimTec | ST4019615 |
| ZINC000098210492 | KeyOrganics | AS-8081 |
| ZINC000100506795 | TimTec | ST50222762 |
| ZINC000238901709 | TimTec | ST100643 |
| ZINC000004623615 | TimTec | ST4104620 |
| ZINC000100032716 | TimTec | ST45053787 |
| ZINC000584578353 | PI Chemicals | PI-31452 |
| ZINC000006661600 | Ambeed | A107950 |
| ZINC000225434673 | Ambinter | Amb22349288 |
| ZINC000006599408 | Ambinter | Amb17836664 |
| ZINC000038586996 | Ambinter | Amb19958926 |
| ZINC000001735150 | NCI Plated 2007 | 200689 |
| Deposited Data | ||
| RNA sequencing datasets | This study | BioProject ID: PRJNA598708 |
| Experimental Models: Organisms/Strains | ||
| Mouse: BALB/c | Charles River | 028 |
| Mouse: C57BL/6 | Charles River | C57BL/6NCrl |
| Oligonucleotides | ||
| TAGCCGGGCAGATGCCCGGCAAGAGAGAATTACAC TTCGGTTAAGGTGATATTCCGGGGATCCGTCGACC |
This study | AB5044 |
| ACCTTGTAATCTGCTGGCACGCAAAATTACTTTCAC ATGGAGTCTTTATGTGTAGGCTGGAGCTGCTTCG |
This study | AB5045 |
| tgcaaaataatatgcaccacgacggcggtcagaaaaataa | This study | AB5046 |
| gaagcgttacttcgcgatctgatcaacgattcgtggaatc | This study | AB5047 |
| Software and Algorithms | ||
| Chemprop | K. Yang et al, 2019 | https://github.com/swansonk14/chemprop |
| RDKit | Landrum, 2006 | https://github.com/rdkit |
| BWA | Li et al, 2009 | https://github.com/lh3/bwa |
| DESeq2 | Love et al, 2014 | https://bioconductor.org/packages/release/bioc/html/DESeq2.html |
| edgeR | Robinson et al, 2010 | https://bioconductor.org/packages/release/bioc/html/edgeR.html |
| GenomeView | Abeel et al, 2012 | https://genomeview.org |
| EcoCyc Pathway Tools | Keseler et al, 2013 | https://ecocyc.org |