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. 2021 Jun 18;3(1):vdab076. doi: 10.1093/noajnl/vdab076

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© The Author(s) 2021. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Effect of radiations on LDL-R expression and BBB permeability. (A) Comparison of LDLR protein level in irradiated (2Gy) vs nonirradiated (0Gy) GSCs (GSC1: p8; GSC2: p7; GSC3: p9) evaluated by Western-blot. The quantitative analysis was carried out by normalizing LDLR intensity against total proteins. The results are expressed as mean of LDLR optical density fold change of irradiated GSCs versus nonirradiated cells from 3 independent experiments ± SE. (B) Intracellular DOXO quantification in nonirradiated and irradiated GSCs incubated with mApoE-DOXO-LIPs. Results are expressed as MFI normalized to MFI of nonirradiated cells ± SE. (C) LDLR protein level in hCMEC/D3 cells before (CTR) and after 12 h-incubation with CM from nonirradiated and irradiated GSCs. (D) TEER values of BBB transwell model untreated (CTR) or incubated with GSC conditioned media (CM) before (0Gy) and after radiation (2Gy). *P < .05, **P < .01, ***P < .001.