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Pharmacokinetic Parameters of DTX in Plasma Followed Intravenous Administration of DTX Commercial Injection and RGD-DTX-M
| PK Parameters | DTX Commercial Injection | RGD-DTX-M |
|---|---|---|
| t1/2 (h) | 5.57±0.51 | 13.25±2.54** |
| Cmax (μg/L) | 2014.95±637.67 | 204.46±6.29** |
| tmax (μg/L) | 0 | 0 |
| AUC0-∞ (μg/L·h) | 557.55±14.13 | 1771.65±63.03**** |
| TBC (L/kg·h) | 3.59±0.09 | 1.07±0.12**** |
Abbreviations: AUC, area under the curve; TBC, total body clearance; t1/2, drug half-life; Cmax, maximum concentration.
