Table 1.
Full Factorial Design for the Optimization of MOX-Loaded TPs and LPs
| Factors (Independent Variables) For TPs Design | Levels | ||
| X1: PC concentration | 1% | 3% | |
| X2: Terpene type | Fenchone | Cineole | Limonene |
| Factors (Independent Variables) for LPs Design | Levels | ||
| X1: SAA type | CTAB | DDAB | |
| X2: PC: SAA molar ratio | 1:1 | 1:2 | 1:5 |
| Responses (Dependent Variables) | Constraints | ||
| Y1: EE (%) | Maximize | ||
| Y2: PS (nm) | Minimize | ||
| Y3: PDI | Minimize | ||
| Y4: ZP (mV) | Maximize | ||
Abbreviations: EE%, entrapment efficiency percent; CTAB, cetrimonium bromide; DDAB, didodecyldimethylammonium bromide; MOX, moxifloxacin hydrochloride; PS, particle size; PDI, polydispersity index; PC, phospholipid; ZP, zeta potential; LPs, leciplex; TPs, terpesomes.