Table 3.
Experimental Runs, Independent Variables, and Measured Response of the 21.31 Full Factorial Experimental Design of MOX Loaded TPs and LPs.
| Formulation Code of TPs | PC Concentration (X1) | Terpene Type (X2) | EE% | PS (nm) | PDI | ZP (mV) |
|---|---|---|---|---|---|---|
| TP1 | 1% | Fenchone | 82.32±0.80 | 711.10±61.10 | 0.65±0.03 | −10.30±0.50 |
| TP2 | 3% | Fenchone | 85.96±0.10 | 793.65±8.85 | 0.72±0.01 | −11.82±0.50 |
| TP3 | 1% | Cineole | 79.70±0.06 | 560.10±1.30 | 0.58±0.01 | −4.31±0.06 |
| TP4 | 3% | Cineole | 84.14±0.21 | 578.65±5.65 | 0.56±0.04 | −12.50±0.30 |
| TP5 | 1% | Limonene | 60.45±1.05 | 515.00±5.00 | 0.59±0.027 | −3.87±0.08 |
| TP6 | 3% | Limonene | 66.22±1.29 | 568.35±1.15 | 0.61±0.07 | −12.05±0.15 |
| Formulation Code of LPs | SAA Type (X1) | PC: SAA Molar Ratio (X2) | EE% | PS (nm) | PDI | ZP (mV) |
| LP1 | CTAB | 1:1 | 78.47±0.17 | 102.41±3.39 | 0.28±0.01 | 32.50±0.50 |
| LP2 | DDAB | 1:1 | 74.02±0.79 | 117.75±0.95 | 0.26±0.005 | 32.10±0.70 |
| LP3 | CTAB | 2:1 | 86.50±0.85 | 131.21±1.21 | 0.36±0.02 | 32.20±2.20 |
| LP4 | DDAB | 2:1 | 74.87±0.66 | 145.31±0.66 | 0.34±0.0005 | 42.80±0.80 |
| LP5 | CTAB | 5:1 | 96.85±0.21 | 161.05±1.05 | 0.46±0.005 | 35.00±1.00 |
| LP6 | DDAB | 5:1 | 90.20±0.07 | 169.35±0.55 | 0.55±0.01 | 45.35±0.15 |
Note: Data represented as mean ± SD (n=3).
Abbreviations: EE%, entrapment efficiency percentage; LP, leciplex; MOX, moxifloxacin hydrochloride; PC, phospholipid; PS, particle size; PDI, polydispersity index; TP, terpesomes, and ZP, zeta potential.