Table 5.

Univariate or Multivariate Analysis of OS/DFS and Clinicopathological Parameters in HCC Patients from Our Validation Cohort

(A) Univariate Analysis
	OS							DFS
	HR	HR.95L			HR.95H		p-value	HR	HR.95L		HR.95H		p-value
Gender	0.329	0.118			0.921		0.034	0.389	0.150		1.013		0.053
Age	0.999	0.967			1.032		0.938	0.996	0.964		1.03		0.827
Differentiation grade	2.082	1.184			3.662		0.000	2.210	1.265		3.859		0.005
TNM stage	2.402	1.342			4.297		0.003	2.780	1.545		5.004		0.001
Tumor size	2.687	1.499			4.816		0.001	2.879	1.613		5.138		0.000
Tumor number	1.271	0.724			2.234		0.404	1.378	0.789		2.407		0.259
PVTT	2.205	0.691			7.035		0.182	1.914	1.091		3.36		0.024
AFP	1.648	0.918			2.957		0.094	1.614	0.906		2.875		0.104
Group*	2.026	1.008			4.070		0.047	2.062	1.027		4.14		0.042
(B) Multivariate Analysis
	OS							DFS
	HR		HR.95L	HR.95H		p-value		HR		HR.95L		HR.95H		p-value
Gender	0.317		0.108	0.930		0.037		NA		NA		NA		NA
TNM stage	2.983		1.259	7.067		0.013		3.278		1.436		7.487		0.005
Differentiation grade	1.138		0.604	2.146		0.689		1.135		0.596		2.162		0.700
Tumor size	1.783		0.899	3.538		0.098		0.564		0.063		5.030		0.608
PVTT	0.620		0.277	1.389		0.245		0.505		0.232		1.095		0.084
Group*	2.589		1.243	5.394		0.011		2.460		1.192		5.072		0.015

Notes: *Group is divided by high or low expression level of DTYMK. Bold text indicates a significant difference.

Abbreviations: AFP, alpha fetus protein; PVTT, portal vein tumor thrombosis; NA, not available.