Table 5.
Gene-Specific DNA Methylation Levels
| (A) DNA Methylation Level of Each COMT CpG Site | ||||||||||||||||
| CpG No. | ||||||||||||||||
| CpG No. | 1 | 2 | 3 | 4 | 5 | 6 | Average | |||||||||
| Early | 4.86 | 0.41 | 2.49 | 1.26 | 0.64 | 3.80 | 2.24 | |||||||||
| Adult | 1.75 | 0.45 | 0 | 1.07 | 0.58 | 3.58 | 1.24 | |||||||||
| (B) DNA Methylation Level of Each SLC6A4 CpG Site | ||||||||||||||||
| CpG No. | ||||||||||||||||
| CpG No. | 1 | 2 | 3 | 4 | Average* | |||||||||||
| Early | 3.61 | 10.25 | 0.74 | 1.92 | 4.13 | |||||||||||
| Adult | 2.04 | 8.23 | 0 | 0.92 | 2.80 | |||||||||||
| (C) DNA Methylation Level of Each NRG1 CpG Site | ||||||||||||||||
| CpG No. | ||||||||||||||||
| CpG No. | 1 | 2 | 3 | 4 | 5 | 6 | 7 | Average | ||||||||
| Early | 4.53 | 6.09 | 6.37 | 5.28 | 4.89 | 1.24 | 3.84 | 4.61 | ||||||||
| Adult | 4.94 | 7.13 | 6.87 | 7.53 | 3.7 | 0.45 | 1.06 | 4.53 | ||||||||
| (D) DNA Methylation Level of Each BDNF CpG Site | ||||||||||||||||
| CpG No. | ||||||||||||||||
| CpG No. | 1 | 2 | 3 | 4 | 5 | 6 | Average* | |||||||||
| Early | 8.73 | 8.98 | 24.29 | 8.68 | 11.57 | 5.58 | 11.31 | |||||||||
| Adult | 11.19 | 9.85 | 29.43 | 9.27 | 11.78 | 7.92 | 13.24 | |||||||||
Notes: (A) F(1,11)=1.94, p>0.05; (B) F(1,7)=1.31, *p<0.05; (C) F(1,13)=2.86, p>0.05; (D) F(1,11)=1.47, *p<0.05; Schizophrenic patients with early-onset age were hypermethylated in the analyzed region of SLC6A4 compared to adult-onset age. See Table B for the DNA methylation level of each CpG site. Data is shown by mean±SE. *p<0.05; Schizophrenic patients with early-onset age were hypomethylated in the analyzed region of BDNF compared to adult-onset age. See Table D for the DNA methylation level of each CpG site. Data is shown by mean±SE. *p<0.05.