Fig. 1.

Acute hyperglycemia regulates K⁺ channels in mouse ventricular cardiomyocytes. a Representative voltage-gated K⁺ current traces in normoglycemia and acute hyperglycemia. The transient outward K⁺ current (I_to) and slowly-inactivating K⁺ current (I_K,slow) were inhibited by 3 mmol/L 4-aminopyiridine. Inset shows enlarged I_to. The steady-state K⁺ current (I_SS) was insensitive to 4-aminopyridine. b Representative inward rectifier K⁺ current (I_K1) traces. c I_to was significantly reduced in acute hyperglycemia. d, e I_K,slow and I_SS were unaltered in acute hyperglycemia. f I_to fast and slow inactivation time constants (τ_fast and τ_slow) were unchanged in acute hyperglycemia. g I_to recovery from inactivation was faster in hyperglycemia. h I_K1 increased in acute hyperglycemia. Student’s paired t test, *p < 0.05, **p < 0.01, ***p < 0.001