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. Author manuscript; available in PMC: 2021 Nov 25.
Published in final edited form as: Basic Res Cardiol. 2020 Nov 25;115(6):71. doi: 10.1007/s00395-020-00834-8

Fig. 10.

Fig. 10

K+ channel remodeling and hyperglycemia effects in heart failure. a Representative voltage-gated K+ currents and IK1 traces in normoglycemia and hyperglycemia in transverse aortic constriction (TAC)-induced heart failure (8-week post-TAC) vs. sham mouse myocytes. b K+ current remodeling in TAC. Hyperglycemia further reduced Ito in TAC. c Hyperglycemia slightly enhanced Ito recovery kinetics and increased the markedly downregulated IK1 in TAC. d Normalized qRT-PCR data on expression of Camk2d and Camk2g, hypertrophic markers (Anf, Myh7) and K+ channel genes. ANOVA; *p < 0.05. **p < 0.01, ***p < 0.001 vs. normoglycemia; †p < 0.05, ††p < 0.01, †††p < 0.001 vs. sham