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. 2021 Jul 29;2021:8390165. doi: 10.1155/2021/8390165

Figure 1.

Figure 1

(a) Long noncoding RNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) was upregulated in osteosarcoma (OS) tissues. (b) Survival curve revealed that high MALAT1 expression was associated with a poorer overall survival in OS patients. (c) MALAT1 was upregulated in OS cell lines. The three OS cell lines Saos-2, MG63, and U2OS all had a higher level of MALAT1 expression than the normal osteoblast cell line HfoB1.19. (d, e) MALAT1 knockdown was achieved by MALAT1 small interfering RNA (si-MALAT1), especially in siRNA6108 group. (f, g) Knockdown of MALAT1 increased ratios of apoptotic cells, compared with the si-NC (negative control) group. (h–j) MALAT1 silence increased the percentage of OS cell lines in G0/G1 phase, compared to the si-NC group in MG63 and U2OS cells. ∗p < 0.01.