Table 3.
Median Semiquantitative SARS-CoV-2 Anti-Spike Antibody Immunoassay Results of Heart and Lung Transplant Recipients by Antibody Response
| D1 |
D2 |
|||
|---|---|---|---|---|
| Roche Elecsys | EUROIMMUN | Roche Elecsys | EUROIMMUN | |
| U/mL (IQR) | (IQR) | U/mL (IQR) | (IQR) | |
| n = 183 | n = 54 | n = 183 | N = 54 | |
| Priming dose responders | 2.9 (1.1, 11.5) | 2.4 (2.3, 2.5) | 250 (174, 250) | 9.1 (7.2, 9.4) |
| Booster responders | 0 (0, 0) | 0.2 (0.03, 0.5) | 23.8 (3.9, 244.2) | 5.5 (2.1, 8.0) |
| Non-responders | 0 (0, 0) | 0.1 (0.03, 0.2) | 0 (0, 0) | 0.2 (0.1, 0.5) |
Anti-RBD immunoassay (Roche Elecsys) results are reported as a concentration of immunoglobulin G (IgG) against the target protein with a measurement range of 0.4 to 250 U/mL; results ≥250 U/mL are reported as 250 U/mL. Anti-S1 immunoassay (EUROIMMUN) results are reported as a sample-to-control ratio of optical density. Antibody-positive cut-offs (determined by the manufacturer) were ≥0.80 U/mL for the former and ≥1.1 arbitrary units for the latter. Priming dose responders developed positive results after both D1 and D2. Booster responders developed positive results only after D2. Non-responders maintained negative results after D1 and D2. D1/D2; Dose1/2. RBD; Receptor binding domain.