Table 3.

Neoadjuvant treatment and surgical characteristics of the recurrent rectal tumor

	ReCRT [n = 35]		Long-course CRT [n = 25]		p value
ReCRT group
30.0/30.6 Gy without chemotherapy	1	(2.9)
30.0/30.6 Gy with chemotherapy	34	(97.1)
Completed n(C)RT	32	(94.1)
Long-course CRT group
50.0/50.4 Gy with chemotherapy			25	(100.0)
Completed n(C)RT			24	(96.0)
cCR
Yes	1	(2.9)	5	(20.0)	0.029
Partial	20	(57.1)	13	(52.0)	0.69
No	12	(34.3)	7	(28.0)	0.61
Tumor growth	2	(5.7)	–		0.22
Type of resection					0.24
LAR	–		3	(12.0)	0.035
APR	11	(31.4)	12	(48.0)	0.19
Partial exenteration	3	(8.6)	–		0.13
Total exenteration	9	(25.7)	5	(20.0)	0.61
ASR	1	(2.9)	1	(4.0)	0.81
Other (not organically bound)	11	(31.4)	4	(12.0)	0.17
IOBT					0.046
No	21	(60.0)	21	(84.0)
Yes	14	(40.0)	4	(16.0)
Radicality of resection by PA					0.11
R0	15	(42.9)	17	(68.0)	0.05
R1	18	(51.4)	6	(24.0)	0.033
R2	–		1	(4.0)	0.23
Irresectable	2	(5.7)	1	(4.0)	0.76
pCR					0.66
Yes	3	(8.6)	3	(12.0)
No	32	(91.4)	22	(88.0)
Histology tumor at histopathological evaluation					0.45
Adenocarcinoma	30	(85.7)	22	(88.0)	0.80
Mucinous	2	(5.7)	–		0.22
No rest tumor (pCR)	3	(8.6)	3	(12.0)	0.66
Tumor differentiation grade					0.029
Well	8	(22.9)	9	(36.0)	0.27
Well–moderately	5	(14.3)	9	(36.0)	0.050
Moderately	15	(42.9)	1	(4.0)	0.001
Poorly	2	(5.7)	2	(8.0)	0.73
Irresectable	2	(5.7)	1	(4.0)	0.76
pCR	3	(8.6)	3	(12.0)	0.66

Data are expressed as n (%)

CRT chemoradiotherapy, n(C)RT neoadjuvant (chemo)radiotherapy, cCR clinical complete response, LAR low anterior resection, APR abdominoperineal reaction, ASR abdominosacral resection, IOBT intraoperative brachytherapy, PA pathology, R0 clear resection margins, R1 resection margin ≤1 mm, R2 macroscopic residual tumor, pCR pathological complete response