Table 2:
β coefficients from linear regression of VSQOL on VFL in the BSE adjusting for covariates
| Vision-Specific Quality of Life Measures | VFL in Better Seeing Eye | P-Value | |
|---|---|---|---|
| β coefficient (95% CI)* | MD (dB) of VFL Associated with 5-point Difference in QOL** | ||
|
| |||
| NEI-VFQ-25 | |||
| Item Response Theory | |||
| IRT Task Composite† | 0.80 (0.65, 0.95) | 6.2 | < 0.001 |
| IRT Well-Being Composite‡ | 0.54 (0.42, 0.67) | 9.2 | < 0.001 |
| Classical Test Theory | |||
| CTT Composite§ | 0.38 (0.32, 0.44) | 13.3 | < 0.001 |
| Driving Difficulties∥ | 0.83 (0.70, 0.97) | 6.0 | < 0.001 |
| General Vision | 0.58 (0.44, 0.71) | 8.7 | < 0.001 |
| Near Vision | 0.52 (0.42, 0.62) | 9.6 | < 0.001 |
| Vision-Related Mental Health | 0.48 (0.37, 0.58) | 10.5 | < 0.001 |
| Peripheral Vision | 0.43 (0.34, 0.52) | 11.7 | < 0.001 |
| Distance Vision | 0.38 (0.29, 0.46) | 13.3 | < 0.001 |
| Vision-Related Role Function | 0.34 (0.23, 0.46) | 14.5 | < 0.001 |
| Vision-Related Dependency | 0.30 (0.22, 0.38) | 16.8 | < 0.001 |
| Vision-Related Social Function | 0.23 (0.17, 0.28) | 22.1 | < 0.001 |
| Ocular Pain | 0.17 (0.07, 0.27) | 29.0 | 0.001 |
| Color Vision | 0.06 (0.01, 0.11) | 86.0 | 0.030 |
| General Health Item | |||
| General Health | 0.60 (0.41, 0.79) | 8.4 | < 0.001 |
| SF-12 | |||
| Mental Component Score | 0.08 (0.03, 0.13) | 62.1 | 0.001 |
| Physical Component Score | −0.01 (−0.05, 0.03) | 0.707 | |
VSQOL = Vision-Specific Quality of Life; VFL = Visual Field Loss; BSE = Better Seeing Eye; AFEDS = African American Eye Disease Study; 95% CI = 95% confidence interval; NEI-VFQ-25 = National Eye Institute Visual Function Questionnaire 25-Item; MD = Mean Deviation; IRT = Item Response Theory; CTT = Classical Test Theory; SF-12 = 12-Item Short-Form Health Survey
VFL is presented as mean deviation score in decibels; vision-specific quality of life is assessed by the NEI-VFQ-25; and health-related quality of life is assessed by the SF-12. Data are presented as coefficient (95% CI). The SF-12 and NEI-VFQ-25 scores are adjusted for age, gender, education, employment status, income, acculturation, co-morbidities, health insurance, vision insurance, and visual acuity impairment.
Regression coefficients were transformed per 5-point difference in HRQOL score, a clinically significant difference in VSQOL score.
IRT Task Composite was calculated from a graded response theory model of 13 items from near vision, distance vision, driving, color vision, peripheral vision, and role difficulties subscales.
IRT Well-Being Composite was calculated from a graded response model of 12 items from general vision, dependency on others, mental health, ocular pain, and social functioning subscales.
Composite score is an un-weighted mean of the 12 subscale scores (excluding general health).
Scores could be generated for only 4,574 of the participants who reported that they were currently driving or had driven in the past.