Table 2.

Post-modulator changes in sweat chloride utilizing enrollment and historic sweat chloride values for pre-modulator baseline values.

	GOAL (Cohort 1: G551D/other) (N=131)	GOAL (Cohort 2: R117H/other) (N=59)	GOAL (Cohort 3: Non-G551D Gating/other) (N=18)	PROSPECT (F508del homozygous) (N= 91)
1-month Post Modulator SC Change
N with SC post-modulator	116	41	14	84
Change using SC (mmol/L) at Enrollment:
Mean (SD)	−47.5 (20.1)	−20.4 (14.8)	−56.3 (17.8)	−18.1 (15.3)
95% CI	(−51.2, −43.8)	(−25, −15.7)	(−66.6, −46.1)	(−21.5, −14.8)
Change using Historic SC (mmol/L):
Mean (SD)	−48.8 (23.7)	−26.6 (22.1)	−61 (22.2)	−19.2 (19.2)
95% CI	(−53.2, −44.4)	(−33.5, −19.6)	(−73.9, −48.2)	(−23.3, −15)
3-month Post Modulator SC Change
N with SC post-modulator	111	37	15	76
Change using SC (mmol/L) at Enrollment:
Mean (SD)	−53.0 (21.1)	−23 (15.2)	−52.6 (24.1)	−16.8 (17.7)
95% CI	(−57, −49.1)	(−28, −17.9)	(−65.9, −39.3)	(−20.8, −12.7)
Change using Historic SC (mmol/L):
Mean (SD)	−54.2 (24.2)	−29.2 (21.4)	−56.2 (28.5)	−18.5 (19.2)
95% CI	(−58.8, −49.6)	(−36.3, −22)	(−72, −40.5)	(−22.9, −14.1)
6-month Post Modulator SC Change
N with SC post-modulator	110	41	14	58
Change using SC (mmol/L) at Enrollment:
Mean (SD)	−53.2 (22.6)	−25.6 (16.1)	−42.6 (38.2)	−16.4 (16.9)
95% CI	(−57.5, −48.9)	(−30.7, −20.5)	(−64.7, −20.6)	(−20.8, −12)
Change using Historic SC (mmol/L):
Mean (SD)	−55.3 (26.2)	−30.7 (19.8)	−52.3 (38.5)	−17.2 (19.9)
95% CI	(−60.2, −50.3)	(−37, −24.5)	(−74.5, −30)	(−22.5, −12)