Table 1.
Summary of 15 cases of post-ChAdOx1 vaccine GBS.
| Author (n) | Country | Sex/Age | Time to onset/nadir (days) | Clinical presentation | Limb NCS | CSF WBC (/μl) | CSF protein (mg/dl) | Ganglioside antibodies | Severity at nadir | Treatment | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Marammatom et al. (7) | India | F/43 | 10/20 | Quadriparesis, facial diplegia | Demyelinating | 2 | 85 | NA | MRCSS 8 Respiratory failure |
IVIg, MV | Full recovery |
| F/67 | 14/16 | Quadriplegia, facial diplegia, abducens palsy, bulbar palsy, distal pinprick impairment | Axonal | 3 | 345 | Negative | MRCSS 4 Respiratory failure |
IVIG, PE, MV | Bed-bound | ||
| F/53 | 12/16 | Quadriplegia, facial diplegia, right facial and tongue numbness, lower limb pinprick and vibration impairment | Demyelinating | 3 | 120 | Negative | MRCSS 8 Respiratory failure |
IVIg, MV | |||
| F/68 | 14/18 | Quadriplegia, facial diplegia, bulbar palsy, limb numbness | Demyelinating | 4 | 75 | Negative | MRCSS 7 Respiratory failure |
IVIg, MV | |||
| M/70 | 11/NA | Quadriparesis, facial diplegia, limb numbness, bulbar palsy | Demyelinating | NA | NA | NA | MRCSS 24 Respiratory failure |
IVIg, MV | |||
| F/69 | 12/NA | Quadriplegia, facial diplegia, ophthalmoplegia, bulbar palsy, distal limb numbness | Demyelinating | NA | NA | NA | MRCSS 30 | IVIG, PE | |||
| F/69 | 13/NA | Quadriplegia, facial diplegia, bulbar palsy, distal limb numbness | Demyelinating | 2 | 83 | NA | MRCSS 2 Respiratory failure |
IVIG, MV | |||
| Allen et al. (4) | UK | M/54 | 12/16 | Distal dysesthesia, facial diplegia | Normal (limb) | 19 | 163 | Negative | MRCSS 60 | Oral steroid | NA |
| M/20 | 22/23 | Distal dysesthesia, facial diplegia | Normal (limb) | 14 | 123 | Negative | MRCSS 60 | Oral steroid | |||
| M/57 | 11/23 | Back pain, facial diplegia, distal dysesthesia | Normal (limb) | 8 | 247 | Negative | MRC 3–4 (UL), 4–5 (LL) | IVIg | |||
| M/55 | 22/31 | Lower limb paresthesia and numbness, facial diplegia | NA | 4 | 89 | Negative | MRCSS 60 | None | |||
| Patel et al. (1) | M/37 | 14/NA | Distal paresthesia, quadriparesis | Axonal | <1 | 177 | NA | MRCSS 44 | IVIg | Slow recovery | |
| Azam et al. (1) | M/67 | 15/NA | Quadriparesis with facial diplegia | Demyelinating | 0 | 390 | Negative | MRC NA (UL), 3 (LL) SIADH |
IVIg | Partial recovery | |
| Min et al. (2) | South Korea | M/58 | 3/12 | Distal dysesthesia (clinically pure sensory) | Demyelinating | 2 | 70 | Negative | MRCSS 60 Severe pain |
Neuropathic pain drugs | Partial response |
| F/37 | 4/16 | Normal | NA | NA | Negative |
Abbreviations: NCS, nerve conduction study; CSF, cerebrospinal fluid; F, female; M, male; NA, not available; WBC, white blood cell; MRCSS, medical research council sum score; MRC, medical research council; UL, upper limb; LL, lower limb; SIADH, syndrome of inappropriate antidiuretic hormone secretion; IVIG, intravenous immunoglobulin; MV, mechanical ventilation; PE, plasma exchange.