Table 1.

Progesterone's regulatory actions on COVID-19 pathogenesis.

Hypoxia	Airway smooth muscle relaxation, regulates microvascular leakage in airways, increases alveolar ventilation
Hypertension	Vasodialator, lowers blood pressure, regulates vascular tone. inhibits coronary hyperactivity
Low hemoglobin and iron overload	Increases hepcidin production
Thrombocytopenia	Progesterone metabolites regulate platelet aggregation and thrombosis
Electrolytes imbalance	Regulates potassium homeostasis and renal electrolyte balance