Fig. 14.

40-year-old man with no past medical history who presented with hypoxemia from COVID-19. He developed respiratory failure requiring mechanical ventilation and septic shock with multi-organ failure. On hospital day 22 he developed disorientation after extubation with his MRI revealing separate regions of subcortical leukoencephalopathy with associated hematomas and microhemorrhages. (a, b) Axial T2-weighted (FLAIR) images show large but separate regions of subcortical white matter signal abnormality in the frontal, parietal, and temporal lobes. (c-f) Multiple axial susceptibility-weighted (SWI) images show larger foci of hemorrhage associated with the white matter abnormality on T2-weighted (FLAIR) image, as well as more extensive microhemorrhage at the gray white junction and within the brainstem.