Table 3.
The Number and Prevalence (%) of Drug Resistance Mutations Among MSM with ART Failure
| DRM | Total | B | CRF01_AE | CRF07_BC | CRF55_01B | CRF59_01B | Others |
|---|---|---|---|---|---|---|---|
| N=393 | N=20 | N=186 | N=84 | N=84 | N=9 | N=10 | |
| PI | |||||||
| M46I | 1(0.3) | – | – | 1(1.2) | – | – | – |
| K43T | 1(0.3) | – | – | 1(1.2) | – | – | – |
| K20T | 1(0.3) | – | – | – | 1(1.2) | – | – |
| NRTI | |||||||
| M184I/V | 166(42.2) | 8(40.0) | 85(45.7) | 20(23.8) | 45(53.6) | 4(44.4) | 4(40.0) |
| K65R | 107(27.2) | 4(20.0) | 57(30.7) | 11(13.1) | 30(35.7) | 1(11.1) | 4(40.0) |
| K70E/Q/R/T | 53(13.5) | 4(20.0) | 25(13.4) | 6(7.1) | 15(17.9) | 1(11.1) | 2(20.0) |
| Y115F | 51(13.0) | 2(10.0) | 33(17.7) | 3(3.6) | 10(11.9) | – | 3(30.0) |
| D67G/N | 41(10.4) | 4(20.0) | 25(13.4) | 7(8.3) | 4(4.8) | 1(11.1) | – |
| A62V | 22(5.6) | 2(10.0) | 12(6.5) | – | 6(7.1) | 1(11.1) | 1(10.0) |
| L74I/V | 19(4.8) | – | 12(6.5) | 3(3.6) | 4(4.8) | – | – |
| K219E/Q | 16(4.1) | 1(5.0) | 7(3.8) | 1(1.2) | 7(8.3) | – | – |
| T215F/I/Y | 14(3.6) | 1(5.0) | 6(3.2) | 1(1.2) | 6(7.1) | – | – |
| M41L | 12(3.1) | – | 6(3.2) | 2(2.4) | 4(4.8) | – | – |
| V75I/M | 12(3.1) | – | 9(4.8) | – | 3(3.6) | – | – |
| L210W | 2(0.5) | – | – | 1(1.2) | 1(1.2) | – | – |
| F77L | 1(0.3) | – | 1(0.5) | – | – | – | – |
| T69N | 1(0.3) | – | 1(0.5) | – | – | – | – |
| NNRTI | |||||||
| V179D/E | 149(37.9) | 5(25.0) | 45(24.2) | 9(10.7) | 84(100.0) | 1(11.1) | 5(50.0) |
| V106I/M | 101(25.7) | 3(15.0) | 61(32.8) | 12(14.3) | 20(23.8) | 2(22.2) | 3(30.0) |
| K103N/Q | 99(25.2) | 6(30.0) | 40(21.5) | 9(10.7) | 39(46.4) | 3(33.3) | 2(20.0) |
| G190A/S | 64(16.3) | 4(20.0) | 51(27.4) | 4(4.8) | 4(4.8) | – | 1(10.0) |
| Y181C | 64(16.3) | 2(10.0) | 34(18.3) | 5(6.0) | 19(22.6) | 1(11.1) | 3(30.0) |
| Y188C/H/L | 28(7.1) | 2(10.0) | 11(5.9) | 2(2.4) | 12(14.3) | – | 1(10.0) |
| K101E/H/P | 26(6.6) | – | 20(10.8) | 5(6.0) | 1(1.2) | – | – |
| F227L | 26(6.6) | – | 14(7.5) | 9(10.7) | 3(3.6) | – | – |
| H221Y | 19(4.8) | 1(5.0) | 12(6.5) | – | 5(6.0) | – | 1(10.0) |
| E138A/G | 13(3.) | 1(5.0) | 2(1.1) | 1(1.2) | 9(10.7) | – | – |
| M230L | 11(2.8) | – | 7(3.8) | – | 4(4.8) | – | – |
| V108I | 10(2.5) | – | 5(2.7) | – | 4(4.8) | – | 1(10.0) |
| P225H | 8(2.0) | 2(10.0) | 4(2.2) | – | 2(2.4) | – | – |
| L100I | 7(1.8) | 2(10.0) | 1(0.5) | – | 3(3.6) | – | 1(10.0) |
| A98G | 5(1.3) | – | 3(1.6) | – | 2(2.4) | – | – |
| K238T | 3(0.8) | – | 1(0.5) | – | 2(2.4) | – | – |
| L234I | 2(0.5) | – | 2(1.1) | – | – | – | – |
Note: The major mutations were denoted by bolding.