Table 4.
Distributions of HIV-1-Infected MSM with ART Failure Within the Three Major Transmission Networks
| Variables | CRF01_AE Sequences | P For Fisher Exact Tests | CRF07_BC Sequences | P for Fisher Exact Tests | CRF55_01B Sequences | P for Fisher Exact Tests | |||
|---|---|---|---|---|---|---|---|---|---|
| Within Transmission Network, n=27(n/N, %) | Total Sequences N=186 | Within Transmission Network, n=33(n/N, %) | Total Sequences N=84 | Within Transmission Network, n= 52(n/N, %) | Total Sequences N=84 | ||||
| Age(years) | |||||||||
| 15–35 | 19(15.2) | 125 | 0.929 | 21(41.2) | 51 | 0.750 | 29(64.4) | 45 | 0.935 |
| 36–50 | 7(13.2) | 53 | 10(40.0) | 25 | 21(60.0) | 35 | |||
| ≥51 | 1(12.5) | 8 | 2(25.0) | 8 | 2(50.0) | 4 | |||
| Occupation | |||||||||
| Student | 1(25.0) | 4 | 0.482 | 4(66.7) | 6 | 0.319 | 3(75.0) | 4 | 0.845 |
| Farmer | 2(20.0) | 10 | 2(50.0) | 4 | 2(66.7) | 3 | |||
| Employed | 14(17.5) | 80 | 16(45.7) | 35 | 29(63.0) | 46 | |||
| Unemployed | 4(8.7) | 46 | 6(28.6) | 21 | 12(60.0) | 20 | |||
| Unknown | 6(13.0) | 46 | 5(27.8) | 18 | 6(54.6) | 11 | |||
| Marital status | |||||||||
| Unmarried | 20(14.7) | 136 | 0.802 | 27(45.0) | 60 | 0.112 | 31(64.6) | 48 | 0.638 |
| Married or cohabiting | 5(12.5) | 40 | 5(22.7) | 22 | 15(53.6) | 28 | |||
| Divorced or separated | 2(20.0) | 10 | 1(50.0) | 2 | 6(75.0) | 8 | |||
| WHO classification | |||||||||
| I | 5(17.2) | 29 | 0.604 | 4(33.3) | 12 | 0.342 | 10(90.9) | 11 | 0.157 |
| II | 3(17.7) | 17 | 5(27.8) | 18 | 8(53.3) | 15 | |||
| III | 18(15.0) | 120 | 21(42.0) | 50 | 28(56.0) | 50 | |||
| IV | 1(5.0) | 20 | 3(75.0) | 4 | 6(75.0) | 8 | |||
| Geographical region | |||||||||
| Pearl River Delta | 24(15.1) | 159 | 0.274 | 30(40.0) | 75 | 0.392 | 42(59.2) | 71 | 0.476 |
| Eastern | 0(0.0) | 6 | 0(0.0) | 1 | 3(75.0) | 4 | |||
| Western | 3(27.3) | 11 | 0(0.0) | 3 | 5(83.3) | 6 | |||
| Northern | 0(0.0) | 10 | 3(60.0) | 5 | 2(66.7) | 3 | |||
| Treatment duration(year) | |||||||||
| <1 | 12(16.4) | 73 | 0.311 | 4(21.1) | 19 | 0.176 | 22(57.9) | 38 | 0.693 |
| 1–3 | 9(11.0) | 82 | 21(41.2) | 51 | 23(62.2) | 37 | |||
| >3 | 6(19.4) | 31 | 8(57.1) | 14 | 7(77.8) | 9 | |||
| Baseline CD4+T cell count (cells/mm3) | |||||||||
| ≤200 | 17(12.8) | 133 | 0.356 | 9(26.5) | 34 | 0.068 | 31(59.6) | 52 | 0.500 |
| >200 | 10(18.9) | 53 | 24(48.0) | 50 | 21(65.6) | 32 | |||
| Viral load (log10) | |||||||||
| 3~ | 3(5.9) | 51 | 0.015 | 15(33.3) | 45 | 0.287 | 15(60.0) | 25 | 0.662 |
| 4~ | 21(21.9) | 96 | 16(50.0) | 32 | 24(66.7) | 37 | |||
| ≥5 | 3(7.7) | 39 | 2(28.6) | 7 | 13(56.6) | 22 | |||
| Drug resistance | |||||||||
| Yes | 16(12.2) | 131 | 0.178 | 5(16.7) | 30 | 0.002 | 37(54.4) | 68 | 0.021 |
| No | 11(20.0) | 55 | 28(51.9) | 54 | 15(93.8) | 16 | |||