FIGURE 4.

Immunity‐and‐matrix regulatory cells (IMRCs) enhanced hippocampal synaptic plasticity in 5×FAD mice. (a), (b), Long‐term potentiation (LTP) in the hippocampal CA1 region was induced by high‐frequency stimulation (HFS); 5×FAD^M‐IV, intravenous (IV) IMRC administration; 5×FAD^M‐ICV, intracerebroventricular (ICV) IMRC administration; 5×FAD^NaCl, IV NaCl treatment. (A), Averaged slopes of baseline normalized field excitatory postsynaptic potentials (fEPSPs). (B), Quantification of mean fEPSP slopes during the last 10 min of the recording after LTP induction (n = 10 slices per group from 3 mice, mean ± SEM, *p < .05; unpaired Student's t test). (C), (D), Representative confocal images of vGlut1immunostaining in the hippocampus of 5× FAD mice administered IMRCs (5×FAD^M‐IV) or NaCl (controls; 5×FAD^NaCl) by tail vein injection (c) and relative quantification (d). Pink, vGlut1; blue, DAPI (n = 5‐6 slices per group from 3 mice). Scale bar, 20 µm; data are presented as means ± SEM; ***P < .001, unpaired Student's t test