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. 2021 Jul 13;54(8):e13087. doi: 10.1111/cpr.13087

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© 2021 The Authors. Cell Proliferation Published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Distribution of granulation tissue and extracellular matrix during healing. A, The HE staining showed the thickness of granulation tissue. B, Statistical data of granulation tissue area during healing process. Staining of interstitial components in granulation tissue. C, Masson staining was used to stain the collagen fibres in the skin sections during the healing process. D, Collagen volume fraction (CVF) during healing process, Vertical axis, CVF; horizontal axis, time. Data are shown as mean ± SE. (*P < .05; **P < .01)