FIGURE 2.

HLA‐iPSC‐NPCs transplantation leads to functional recovery in 11 months‐ol YAC128 transgenic mice. (A) Scheme of the in vivo experiment. Wild‐type (WT) mice were injected with media alone, whereas six‐month‐old YAC128 mice were transplanted with HLA‐iPSC‐NPCs. Behavioural tests were performed every month for six months after transplantation. (B, C) Motor function recovery was monitored every month using the accelerating rotarod and grip strength tests (WT: n = 8, Sham: n = 7, and TP: n = 8, *P <.05, **P <.01 and ***P <.001). (D, E) Cognitive recovery was monitored using the simple swim and novel object recognition tests (WT: n = 8, Sham: n = 7, and TP: n = 8). (D) Simple swim test results. (E) Novel object recognition test results. Data were analysed by two‐way ANOVA followed by a Tukey post hoc test, using the SPSS software