Table 1.
List of microbial-derived natural products with anti-cancer activities
| Anti-cancer compound | Origin | Activity/mechanism | Cancer types or cell lines | References |
|---|---|---|---|---|
| Actinomycin D | Streptomyces sp. ZZ338 | Targeting glycolysis, glutaminolysis and lipogenesis | Glioma cell lines | Zhang et al. (2016) |
| BAEPS exopolysaccharide | Bacillus amyloliquefaciens 3MS 2017 | Inhibition of COX-2, aromatase, Na+/K+ ATPase, and estrogen production | MCF-7 cells | Ibrahim et al. (2020) |
| Bleomycin | Streptoalloteichus hindustanus | Induction of DNA strand breaks |
Testicular cancer Ovarian cancer Hodgkin's lymphoma |
Demain and Vaishnav (2011) |
| Brartemicin | Nonomuraea sp. | Reduction of invasion | 26-L5 cells | Igarashi et al. (2009) |
| Butanol extract | Bifidobacterium adolescentis SPM0212 | Anti-proliferative activity | Caco-2, HT-29 and SW480 cells | Lee et al. (2008) |
|
Butyrate and propionate |
Firmicutes phylum | Apoptotic, anti-proliferative and epigenetic activity | Colon, lung and prostate cancer cells | Górska et al. (2019), Kim et al. 2019) |
| Diethyl ether extract | Streptomyces levis ABRIINW111 | Apoptosis | ALL cells | Valipour et al. (2018) |
| Diterpenoid derivative | Micromonospora zhangzhouensis HM134 | Anti-proliferative activity |
HepG2, HCT-116 and A549 cells |
Fu et al. (2020) |
| Ether extract | Streptomyces levis ABRIINW111 | Cell cycle arrest and apoptosis | SW480 cells | Faramarzian et al. (2018) |
| Ethyl acetate extract | Streptomyces artemisiae MCCB 248 | Induction of nucleus shrinkage, DNA fragmentation and chromatin condensation | H460 cells | Dhaneesha et al. (2017) |
|
Ethyl acetate fraction |
Streptomyces sp. OA293 | Apoptosis | HPV-16-positive SiHa and Caski cells | Dan et al. (2018) |
|
Ethyl acetate fraction |
Streptomyces sp. MUM256 | Cell cycle arrest and apoptosis | HCT-116 cells | Tan et al. (2019) |
| Galvaquinone B | Streptomyces spinoverrucosus | Cytotoxicity and epigenetic activity |
NSCLC, Calu-3 and H2887 cells |
Hu et al. (2012) |
| Geldanamycin | Streptomyces hygroscopicus var. geldanus | HSP90 inhibition-mediated cytotoxicity | Myeloma, breast, prostate and cervical cancer | Gorska et al. (2012) |
| Iturin A | Bacillus megaterium | Cell cycle arrest and apoptosis | Breast cancer cell lines | Dey et al. (2015) |
| Jadomycins | Streptomyces venezuelae | ROS generation | Breast cancer cells | Hall et al. (2015) |
| Komodoquinone A | Streptomyces sp. K53 | Induction of cell differentiation | Neuro2A cells | Itoh et al. (2003) |
| Kosinostatin | Streptomyces violaceusniger HAL64 | Apoptosis | MCF-7 cells | Rambabu et al. (2015) |
| Lentztrehaloses A, B and C | Lentzea sp. ML457-mF8 | Autophagy |
Human melanoma Ovarian cancer |
Wada et al. (2015) |
| Lipophilic peptides | EML-CAP3 bacterial strain | Anti-angiogenic activity by suppressing HIF-1α and VEGF | HepG2 cells | Jung et al. (2015) |
| Mensacarcin | Streptomyces bottropensis | Apoptosis | Melanoma cell lines | Plitzko et al. (2017) |
| Neoantimycin F (NAT-F) | Streptomyces conglobatus | Apoptosis | NSCLC cells | (Liu et al. 2019) |
| Novobiocin | Streptomyces strain | Anti-proliferative activity | Breast cancer cell lines | Donnelly and Blagg (2008) |
| N-acetyl-deformylantimycin | Streptomyces sp. strain THS-55 | Induction of ROS-mediated ubiquitin–proteasome system, degradation and inhibition of ERK1/2, STAT3 | HPV-infected cervical cells | Zhang et al. (2017) |
| Organic extracts | Pseudomonas spp. AS 8, 106 and 70 | Cytotoxicity | MCF-7 cells | Anas et al. (2016) |
| p8 | Lactobacillus rhamnosus (LR) | Slowing cell cycle progression | CRC cells | An et al. (2019) |
| Prodigiosin (PG) | Serratia marcescens | Apoptotic and anti-metastatic activities | Mouse melanoma model | Chang et al. (2011) |
|
Proteinase K-activated parasporin-2Aa 1 protein |
Bacillus thuringiensis strain A1547 | Apoptosis | HepG2, PC-3 and MCF-7 cells | Brasseur et al. (2015) |
|
Pyrrolo (1,2-a) pyrazine-1,4-dione, hexahydro-3-(phenylmethyl) |
Streptomyces MUM256 and MUSC137 | Apoptosis | HT-29 cells | Ser et al. (2017) |
|
Pyrrolo (1,2-a) pyrazine-1,4-dione, hexahydro 3-(2- methyl propyl) |
Staphylococcus sp. strain MB30 | Cell cycle arrest and apoptosis | A549 and HPV18 positive HeLa cells | Lalitha et al. (2016) |
|
Proteinase K-activated parasporin-2Aa 1 protein |
Bacillus thuringiensis strain A1547 | Apoptosis | HepG2, PC-3 and MCF-7 cells | Brasseur et al. (2015) |
| Quercetin-3-O-b-L-rhamnopyranosyl- (1 to 6)-b-D-glucopyranoside | Streptomyces sp. ERINLG-4 | Apoptosis | A549 cells | Balachandran et al. (2014) |
| Romidepsin | Chromobacterium violaceum | Inhibition of HDAC | CTCL and PTCL | Furumai et al. (2002) |
| Salinomycin | Streptomyces albus | Inhibition of VEGF-VEGFR2-Akt/FAK signaling pathway | Glioma cell lines | Bi et al. (2017) |
| Trichostatin A | Streptomyces hygroscopicus | Inhibition of HDAC and anti-proliferative activity | MCF-7, T-47D, ZR-75-1, BT-474, MDA-MB-231, MDAMB-453, CAL 51, SK-BR-3 cells | Vigushin et al. (2001) |
| Cell cycle arrest and apoptosis | T24 cells | Qu et al. (2010) | ||
| Urukthapelstatin A | Merchercharimyces asporophorigenes YM11-542 | Cytotoxicity | A549 cells | Matsuo et al. (2007) |
| Valinomycins and compounds 1 and 2 | Crude extract of Streptomyces sp. ZZ406 | Anti-proliferative activity | U87 MG cells | Chen et al. (2018a, b, c) |
| Violacein | Chromobacterium, Janthinobacterium, Alteromonas, Duganella, Massilia, Pseudoalteromonas and Collimonas | Anti-proliferative activity | HeLa cells | Alem et al. (2020) |
| Chromobacterium violaceum | Chemosensitization to 5-Fluorouracil | CACO-2, DLD-1, SW480 and HCT-116 cells | Kodach et al. (2006) |