Fig. 2.

Permutation analysis of the differences in SNR for aggregate mutation data. The distribution of the difference in signal to noise ratio (SNR) values for 100 random permutations of the aggregate MSS and MSI data. Permutations preserve the difference in the number of mutations between the MSS and MSI data. Plots show the distribution of SNR differences for (A) translational periodicity and (B) rotational periodicity. Red bars represent the median of each data set and the red points highlighted by the arrows represents the difference between the original MSS vs MSI data (Fig. 1). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)