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. 2021 Jun 2;83(7):1161–1166. doi: 10.1292/jvms.20-0519

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©2021 The Japanese Society of Veterinary Science

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)

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Fig. 1. — Relative mRNA expression of inflammasome sensor subunits in the duodenal mucosa of dogs with chronic enteropathy (CE). Expression levels of nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing (NLRP)3 (A and B), NLRP6 (C and D), and NLRP12 (E and F) mRNA were analyzed by real-time PCR in healthy dogs (n=7) and those with CE (n=35), which included dogs with antibiotic-responsive enteropathy (ARE) (n=4), food-responsive enteropathy (FRE) (n=11), and immunosuppressant-responsive enteropathy (IRE)/non-responsive enteropathy (NRE) (n=20). The horizontal lines in each group represent the mean value. Relative mRNA expression was compared between healthy dogs and those with CE by the Mann–Whitney U test (A and E) or the unpaired t-test (C). Relative mRNA expression was compared among healthy dogs and those with ARE, FRE, or IRE/NRE by the Kruskal–Wallis test (B and F) or the one-way ANOVA (D).