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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: J Affect Disord. 2021 Jun 25;293:355–362. doi: 10.1016/j.jad.2021.06.040

Figure 5. Effects of MDD History and E2 on the correlation between Change in Activity during the MIST and Subjective Stress.

Figure 5.

A) Women with a history of MDD who received estradiol showed a negative correlation between activity in the right inferior frontal region during the “stress” condition (compared to “rest”) of the Montreal Imaging Stress Task (MIST)and Stress-Arousal Checklist (SACL) Stress change score with less activity associated with greater subjective stress. B) Women with a history of MDD who did not receive estradiol showed a positive correlation between activity in the right temporal/ insula region during the “stress” condition of the MIST (compared to “rest) and SACL-Stress change score and also between activity change between the “control” and “stress” conditions and SACL-Stress change score with greater activity associated with greater subjective stress.