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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: J Affect Disord. 2021 Jun 25;293:355–362. doi: 10.1016/j.jad.2021.06.040

Table 1.

fMRI Analyses and Results

fMRI Analysis Results Regions
A) Effect of MIST Task “Stress” Condition:
“Stress” – “Control”
All Participants		 Increased Activity During “Stress” Right Superior / Middle Temporal
Right Middle Occipital / Cuneus
Decreased Activity During “Stress” Left Middle Frontal / Anterior Cingulum
Left Caudate / Inferior Frontal / Insula
Right Caudate
Left Angular
B) Effects of MDD History and E2:
“Stress” – “Control”
MDD History and E2 as factors		 MDD History, E2 Interaction Left Inferior Frontal
Left Angular Gyrus
Correlations between activity and SACL-Stress Score Left Angular Gyrus:
 Negative Correlation in MDD-/E2+
Left Angular Gyrus
 Positive Correlation in MDD-/E2-
C) Correlation between Activity and Subjective Stress:
“Stress” – “Control”
All Participants
SACL-Stress Score as Covariate		 Positive Correlation between Activity and SACL-Stress Score No Significant Regions
Negative Correlation between Activity and SACL-Stress Score Left Precentral
Posterior Cingulum / Precuneus
Left Angular / Supramarginal
Left Precentral Gyrus
Left Inferior Temporal
Left Superior Temporal
Left Superior Temporal
Anterior Cingulum
Left Inferior / Middle Temporal
Supplementary Motor Area
Right Superior / Middle Temporal
D) Group Differences in Correlations between Activity and Subjective Stress:
“Stress” – “Control”
Group as factor
SACL-Stress Score as Covariate		 Correlations between Activity and SACL-Stress Score Right Inferior Frontal:
 Positive correlation in MDD+/E2+
Right Temporal/ Insula:
 Positive Correlation in MDD+/E2-