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. Author manuscript; available in PMC: 2022 Aug 6.
Published in final edited form as: Circ Res. 2021 Jun 28;129(4):458–470. doi: 10.1161/CIRCRESAHA.121.319163

Figure 5: Adamts7 dosage and catalytic dependent effects on the ApoE KO atherogenic background.

Figure 5:

Mice from heterozygous intercrosses for the tm1b loss of function allele or the E373Q catalytic mutant allele, were challenged with 10 weeks of high fat diet to stimulate atherosclerosis on the ApoE KO background. The mice were euthanized at 20 weeks of age for evaluation of atherosclerosis. A and D, Representative photomicrographs of Oil-Red O staining and quantitative analysis of atherosclerotic lesion area in the aortic arch. B, male WT vs Adamts7 +/− (HET) vs Adamts7 −/− (KO), n=14 to 18 per group; C, female WT vs HET vs KO, n=10 to 19 per group; E, male WT vs +/EQ vs EQ/EQ, n=9 to 14 per group; F, female WT vs +/EQ vs EQ/EQ, n=11 to 17 per each group. Data points represent individual animals, error bars indicate means ±SEM, and two-way ANOVA with Tukey’s test was applied. Normality was tested by Kolmogorov-Smirnov test. *P<0.05, **P<0.01.