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. 2021 Jun 4;19(8):1398–1411. doi: 10.1158/1541-7786.MCR-21-0014

Figure 4.

Figure 4.

Knockdown of METTL3 in prostate cancer alters protein expression. A, Correlation (Spearman ρ = 0.4685, P < 1E-15) between the average mRNA expression (n = 3) and protein expression (n = 3) as determined by shotgun proteomics in the NT shRNA line. B, Significantly (adjusted P value < 0.05) differentially expressed proteins with METTL3 knockdown in the two inducible shRNA lines as compared with the NT shRNA line (n = 3 for each shRNA). Common highly differentially expressed proteins between the two shRNA lines are highlighted with a black border. C, The top 60 differentially expressed proteins seen with METTL3 knockdown in both shRNA lines as compared with the NT control (n = 3 for each shRNA). D, Gene set enrichment analysis of proteins differentially expressed with METTL3 knockdown. Proteins were ranked according to the log of the adjusted P value as determined by t test. Shown are the top 20 results in either direction.