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Physicochemical Properties; Human and Rat Hepatic Clearance and Free Fraction Data for Compounds 8b and 20a.a
| Compound | MW | tSPA | hClhep(mL/min/kg) | rClhep(mL/min/kg) |
fu (plasma, rat) |
fu (brain, rat) |
fu (plasma, human) |
|---|---|---|---|---|---|---|---|
| 8b | 378.4 | 48.3 | 10.4 | 43 | 0.040 | 0.042 | 0.050 |
| 20a | 463.5 | 60.7 | 18.6 | 58.7 | 0.027 | 0.019 | 0.025 |
See ref. 20 for experimental details.
