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. 2021 Jul 31;23(9):966–978. doi: 10.1016/j.neo.2021.07.010

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© 2021 The Authors. Published by Elsevier Inc.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — High levels of Hpa2 are associated with longer survival of gastric cancer patients. (A) Immunostaining. Tumor biopsies and adjacent normal gastric tissues were subjected to immunostaining applying anti-Hpa2 antibody. Shown are representative images of Hpa2 staining in normal gastric tissue (left) and gastric carcinoma stained negative (middle) and positive (right) for Hpa2. Original magnifications: x10 (upper panels), x100 (lower panels). (B) Kaplan-Meier survival plot. Kaplan-Meier survival analysis of gastric cancer patients according to their Hpa2 staining intensities (high vs low). Gastric carcinoma patients exhibiting strong staining of Hpa2 (n = 56) survive significantly longer than patients that show low levels of Hpa2 (n = 79; P= 0.004). Hpa2, heparanase 2.