Table 7:

Dysregulation of GABAergic, glutamatergic, and solute carrier genes in cerebellum and frontal/parietal lobes of the patient

	Subunit	Cere	Frontal	Parietal	Comment
GABAAR	α2	−2.56
	α4	−2.77		2.32
	α5	−4.19	2.12	2.63
	α6			−2.34
	β1	−4.84	−2.26	−4.46
	β3			2.49
	δ			−2.56
	ε	−3.95	−4.71	−7.71
	γ1	−2.35
	γ2			2.0
	γ3	−4.37
	θ	−3.08	−3.35	−8.81
	ρ1	−2.73	−3.18	−9.86
	ρ2		−3.69	−9.86
GABABR	R2			−2.3
Glu R	A1	−2.92			Ionotropic AMPA 1
	A4			−2.17	Ionotropic AMPA 4
	K5			−3.31	Ionotropic kainate 5
	N1			−2.22	Ionotropic NMDA 1
	1			−2.11	Metabotropic 1
	5			−2.82	Metabotropic 5
	6	−2.1	−4.0	−5.87	Metabotropic 6
	8				Metabotropic 8
SLC	17A6	−3.37	−2.18	−2.21	Na+-dependent Pi cotransporter member 6
	17A8	−2.62			Na+-dependent Pi cotransporter member 8
	1A3	−3.67	2.26		Glial high affinity glu transporter member 3
	1A6	−2.18			High affinity asp/glu transporter member 6
	6A13	−2.89	−2.02	−7.3	Neurotransmitter transporter, GABA, member 13
	7A11		2.57		Anionic amino acid transporter, light chain, xc− system member 11

All values shown significant at p<0.05. Negative, down-regulation; positive, up-regulation.

Abbreviations: R, receptor; cere, cerebellum; glu, glutamate; SLC, solute carrier; AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; NMDA, N-methyl-D-aspartate; asp, aspartate; P_i, inorganic phosphate; xc⁻, cystine-glutamate antiporter. Of the 51 genes evaluated for expression levels, 29 revealed dysregulations in at least one tissue from the patient.