Table 8:
Dysregulation of miscellaneous genes associated with GABAergic/glutamatergic signaling in cerebellum and frontal/parietal lobes of the patient
| Gene | Cere | Frontal | Parietal | Comment |
|---|---|---|---|---|
| IL1β | −3.78 | −2.93 | −9.86 | Interleukin 1, β |
| ITPR1 | −2.32 | −2.4 | Inositol 1,4,5-triphosphate receptor, type 1 | |
| P2RX7 | −2.81 | −2.03 | Purinergic receptor P2X, ligand-gated ion channel, 7 | |
| ADCY7 | −2.4 | Adenylate cyclase 7 | ||
| SHANK2 | −2.08 | −2.97 | SH3 and multiple ankyrin repeat domains 2 | |
| ADORA2A | −2.98 | Adenosine A2a receptor | ||
| CACNA1A | −2.21 | Calcium channel, voltage dependent, P/Q type, α1A subunit | ||
| CACNA1B | −3.02 | Calcium channel, voltage dependent, N type, α1A subunit | ||
| CLN3 | −2.17 | Ceroid lipofuscinosis, neuronal 3 | ||
| PLA2G6 | −2.35 | Phospholipase A2, group VI (cytosolic, Ca+2-independent | ||
| PLCB1 | −2.11 | Phospholipase C, β1 (phosphoinositide specific) | ||
| MAPKI | 6.54 | Mitogen-activated protein kinase 1 | ||
| SNCA | 5.08 | 4.88 | 6.52 | Synuclein, α (non A4 component of amyloid precursor) |
| AVP | −2.34 | −2.95 | Arginine vasopressin |
All values shown significant at p<0.05. Negative, down-regulation; positive, up-regulation.
Abbreviations: Of the 38 genes evaluated for expression levels, 15 revealed dysregulations in at least one tissue from the patient. This group of genes contained 38 genes in total, for which the fifteen shown in the table were dysregulated in at least one of the patient’s tissues.