Systematic reviews are scientific investigations which seek to answer a specific research question through the collection and critical assessment of all evidence meeting pre-specified criteria.15 When conducting a systematic review, it is imperative that investigators use explicit and pre-specified methods to identify, select, appraise, and summarize all available evidence.15 A systematic review should synthesize evidence qualitatively and may also include a “meta-analysis”: the quantitative combination of results from independent studies. |