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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Ophthalmol Glaucoma. 2021 Feb 9;4(5):454–462. doi: 10.1016/j.ogla.2021.01.007
Systematic reviews are scientific investigations which seek to answer a specific research question through the collection and critical assessment of all evidence meeting pre-specified criteria.15 When conducting a systematic review, it is imperative that investigators use explicit and pre-specified methods to identify, select, appraise, and summarize all available evidence.15 A systematic review should synthesize evidence qualitatively and may also include a “meta-analysis”: the quantitative combination of results from independent studies.