TABLE 3.
Fatigue, depression, quality of life, and executive functioning in sarcoidosis patients with versus without chronic fatigue.
| CF (n = 19) | NCF (n = 11) | Between-group difference [95%CI] | p-value | dCohen | |
| MFI total | 66.9 ± 10.0 | 39.5 ± 9.4 | 27.4 [19.8, 35.0] | <0.001* | −2.76 |
| MFI general fatigue | 14.6 ± 2.7 | 8.3 ± 2.9 | 6.4 [4.2, 8.5] | <0.001* | −2.27 |
| MFI physical fatigue | 14.5 ± 2.1 | 8.8 ± 3.3 | 5.7 [3.7, 7.6] | <0.001* | −2.32 |
| MFI red. activity | 13.7 ± 2.8 | 8.4 ± 2.2 | 5.4 [3.4, 7.4] | <0.001* | −2.04 |
| MFI red. motivation | 11.2 ± 3.0 | 7.1 ± 2.5 | 4.1 [1.9, 6.3] | 0.001* | −1.45 |
| MFI mental fatigue | 12.9 ± 3.2 | 7.0 ± 3.0 | 5.9 [3.5, 8.3] | <0.001* | −1.89 |
| FAS total | 32.1 ± 6.1 | 18.5 ± 5.3 | 13.7 [9.1, 18.2] | <0.001* | −2.33 |
| FIS total | 80.0 ± 23.7 | 25.3 ± 21.7 | 54.7 [36.9, 72.6] | <0.001* | −2.38 |
| ADS | 17.6 ± 9.8 | 4.5 ± 4.0 | 13.1 [6.8, 19.5] | <0.001* | −1.6 |
| DESC-I | 7.5 ± 7.3 | 0.6 ± 1.0 | 6.9 [2.3, 11.5] | 0.001* | −1.17 |
| DESC-II | 8.4 ± 7.4 | 1.6 ± 3.6 | 6.8 [1.9, 11.7] | 0.009 | −1.08 |
| HAMD | 4.1 ± 2.1 | 2.7 ± 0.8 | 1.4 [0.2, 2.6] | 0.029 | −0.8 |
| STAI-X1 | 38.3 ± 9.0 | 29.3 ± 6.0 | 9.0 [2.8, 15.3] | 0.006 | −1.12 |
| STAI-X2 | 44.6 ± 10.3 | 30.3 ± 6.9 | 14.3 [7.1, 21.5] | <0.001* | −1.55 |
| WHOQOL-BREF global domain | 45.4 ± 20.9 | 76.1 ± 14.2 | −30.7 [−43.9, −17.5] | <0.001* | 1.63 |
| WHOQOL-BREF physical health domain | 49.4 ± 22.2 | 81.2 ± 10.5 | −31.7 [−44.0, −19.4] | <0.001* | 1.69 |
| WHOQOL-BREF psychologic health domain | 63.4 ± 18.9 | 78.8 ± 7.1 | −15.4 [−25.3, −5.5] | 0.004 | 0.979 |
| WHOQOL-BREF social relationships domain | 67.5 ± 20.6 | 78.0 ± 15.0 | −10.5 [−25.1, 4.1] | 0.152 | 0.56 |
| WHOQOL-BREF environmental health domain | 74.0 ± 13.6 | 83.2 ± 10.7 | −9.2 [−19.0, 0.6] | 0.064 | 0.73 |
| BSI total | 0.72 ± 0.52 | 0.19 ± 0.17 | −0.5 [−0.8, −0.3] | <0.001* | −1.24 |
| TMT-A | 30.34 ± 16.0 | 26.5 ± 10.6 | 3.8 [−7.3, 14.9] | 0.486 | 0.268 |
| TMT-B | 63.3 ± 32.1 | 62.3 ± 25.1 | 1.0 [−22.1, 24.2] | 0.927 | −0.035 |
| Difference TMT-B minus -A | 32,9 ± 26,8 | 35,7 ± 27,0 | −2,7 [−23.6, 18,1] | 0.787 | −0.103 |
Data are presented as mean ± standard deviation. Significant results after Bonferroni correction are marked with *. Magnitude of effect size is given by dCohen. ADS: Allgemeine Depressionsskala (General Depression Scale); BSI: Brief Symptom Inventory; DESC: Rasch-basiertes Depressionsscreening (Depression Screening); FAS: Fatigue Assessment Scale; FIS: Fatigue Impact Scale; HAMD: Hamilton Depression Scale; STAI: State-Trait Anxiety Inventory; TMT: Trail Making Test; WHOQOL-BREF: World Health Organization quality of life assessment short form.