Table 2.

The number of patients with successful sedation and assessment methods of successful sedation in endoscopy.

References	Study design	No. of patients in each group		No. of successful sedation		Assessment methods of successful sedation
		Remimazolam	Control	Remimazolam	Control
Borkett et al. (20)	RCT	0.10 mg/kg: 25 0.15 mg/kg: 25 0.20 mg/kg: 25	Midazolam: 25	0.10 mg/kg: 8 0.15 mg/kg: 14 0.20 mg/kg: 16	Midazolam: 14	(1), (2), (3), (5)
Chen et al. (21)	RCT	194	Propofol:190	188	Propofol: 190	(2), (3), (4)
Chen* et al. (14)	RCT	189	Propofol: 189	184	Propofol: 189	(2), (3), (4)
Pambianco et al. (24)	RCT	8.0/3.0 mg: 40 7.0/2.0 mg: 40 5.0/3.0 mg: 40	Midazolam: 40	8.0/3.0 mg: 37 7.0/2.0 mg: 38 5.0/3.0 mg: 39	Midazolam: 30	(1), (2), (3), (5)
Pastis et al. (12)	RCT	303	Placebo: 63 Midazolam: 73	250	Placebo: 3 Midazolam: 24	(2), (3), (4)
Rex et al. (13)	RCT	296	Placebo: 60 Midazolam: 102	270	Placebo: 1 Midazolam: 26	(2), (3), (4)
Rex et al. (13)	RCT	31	Placebo: 16 Midazolam: 30	27	Placebo: 0 Midazolam: 4	(2), (3), (4)

The successful sedation was defined as follows: (1) MOAA/S ≤ 4 on three consecutive measurements taken every minute; (2) completion of the whole endoscopy procedure; (3) no requirement for an alternative and/or rescue sedative; (4) administered up to a maximum of five supplemental doses within 15 min after the initial dose; (5) no manual or mechanical ventilation.

^*indicates different articles published by the same author in the same year.