Table 3.
The number of patients with adverse events during endoscopy.
| References | Patients in each group (n) | Hypotension (n) | Hypoxia (n) | Bradycardia (n) | ||||
|---|---|---|---|---|---|---|---|---|
| Remimazolam | Control | Remimazolam | Control | Remimazolam | Control | Remimazolam | Control | |
| Borkett et al. (20) | 0.10 mg/kg: 25 0.15 mg/kg: 25 0.20 mg/kg: 25 |
Midazolam: 25 | 0.10 mg/kg: 0 0.15 mg/kg: 0 0.20 mg/kg: 0 |
Midazolam: 1 | 0.10 mg/kg: 4 0.15 mg/kg: 5 0.20 mg/kg: 6 |
Midazolam:5 | NA | NA |
| Chen et al. (21) | 194 | Propofol: 190 | 46 | Propofol: 97 | 6 | Propofol: 32 | 2 | Propofol: 7 |
| Chen* et al. (14) | 189 | Propofol: 189 | 24 | Propofol: 81 | 2 | Propofol: 13 | NA | NA |
| Pambianco et al. (24) | 8.0/3.0 mg: 40 7.0/2.0 mg: 40 5.0/3.0 mg: 40 |
Midazolam: 40 | 8.0/3.0 mg: 1 7.0/2.0 mg: 1 5.0/3.0 mg: 0 |
Midazolam: 0 | 8.0/3.0 mg: 1 7.0/2.0 mg: 2 5.0/3.0 mg: 0 |
Midazolam: 1 | NA | NA |
| Pastis et al. (12) | 303 | Placebo: 59 Midazolam: 69 |
127 | Placebo: 37 Midazolam: 34 |
66 | Placebo: 12 Midazolam: 13 |
13 | Placebo: 4 Midazolam: 3 |
| Rex et al. (13) | 296 | Placebo: 60 Midazolam: 102 |
115 | Placebo: 25 Midazolam: 63 |
3 | Placebo: 2 Midazolam: 1 |
33 | Placebo: 7 Midazolam: 16 |
| Rex et al. (13) | 31 | Placebo: 16 Midazolam: 30 |
18 | Placebo: 11 Midazolam: 17 |
6 | Placebo: 2 Midazolam: 8 |
1 | Placebo: 1 Midazolam: 4 |
| Study | Patients in each group (n) | Nausea (n) | Vomiting (n) | Pain of injection site (n) | ||||
| Remimazolam | Control | Remimazolam | Control | Remimazolam | Control | Remimazolam | Control | |
| Borkett et al. (20) | 0.10 mg/kg: 25 0.15 mg/kg: 25 0.20 mg/kg: 25 | Midazolam: 25 | NA | NA | NA | NA | NA | NA |
| Chen et al. (21) | 194 | Propofol: 190 | 5 | Propofol: 1 | 1 | Propofol: 0 | 1 | Propofol: 19 |
| Chen* et al. (14) | 189 | Propofol: 189 | NA | NA | NA | NA | 0 | Propofol: 31 |
| Pambianco et al. (24) | 8.0/3.0 mg: 40 7.0/2.0 mg: 40 5.0/3.0 mg: 40 |
Midazolam: 40 | NA | NA | NA | NA | NA | NA |
| Pastis et al. (12) | 303 | Placebo: 59 Midazolam: 69 |
12 | Placebo: 2 Midazolam: 2 |
6 | Placebo: 1 Midazolam:2 |
2 | Placebo: 0 Midazolam: 0 |
| Rex et al. (13) | 296 | Placebo: 60 Midazolam: 102 |
5 | Placebo: 4 Midazolam: 2 |
3 | Placebo: 2 Midazolam: 0 |
NA | NA |
| Rex et al. (13) | 31 | Placebo: 16 Midazolam: 30 |
NA | NA | NA | NA | NA | NA |
*
indicates different articles published by the same author in the same year.