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. 2021 Jul;10(7):3369–3384. doi: 10.21037/tlcr-20-1134

Figure 2.

Figure 2

Intravasation/extravasation of cancer cells and “seed and soil” theory. JAG-1,2, Jagged ligands 1,2; DLL, delta-like ligand; CTC, circulating tumor cell; RANK/RANK-L, receptor activator of nuclear factor kappa-B/receptor activator of nuclear factor kappa-B ligand; PECAM-1, the platelet and endothelial cell adhesion molecule-1; CDCP1, CUB domain containing protein 1; TME, tumor microenvironment; mets, metastases; ANGPTL4, angiopoietin-like factor 4; VEGF, vascular endothelial growth factor; SDF1, stromal cell-derived factor 1; CXCL12, C-X-C motif chemokine 12; IGF-1R, insulin-like growth factor receptor 1; MSp/TAMS, macrophage-stimulating protein/tumor-associated macrophages; mTOR, mammalian target of rapamycin; EGFR/ERBB2, epidermal growth factor receptor/receptor tyrosine-protein kinase erbB-2; VEGFR-2, vascular endothelial growth factor receptor 2; TILs PD-1 positive, PD-1-positive tumor infiltrating lymphocytes; VCAM-1, vascular cell adhesion molecule-1; CCR6/CCL20, chemokines.