Table 3. HRs of SII on RFS stratified by different clinicopathological factors (n=3,984).
| Variables | HR | 95% CI | P value | |
|---|---|---|---|---|
| Lower | Upper | |||
| Age, years | ||||
| ≤60 | 1.617 | 1.348 | 1.941 | <0.001 |
| >60 | 1.620 | 1.357 | 1.932 | <0.001 |
| Sex | ||||
| Male | 1.397 | 1.195 | 1.633 | <0.001 |
| Female | 1.746 | 1.401 | 2.177 | <0.001 |
| Smoking history | ||||
| Never | 1.648 | 1.376 | 1.974 | <0.001 |
| Ever | 1.379 | 1.150 | 1.654 | 0.001 |
| p-TNM stage | ||||
| 0/I | 1.603 | 1.288 | 1.994 | <0.001 |
| II/III | 0.987 | 0.844 | 1.154 | 0.869 |
| GGO components | ||||
| Absence | 1.238 | 1.084 | 1.415 | 0.002 |
| Presence | 1.257 | 0.801 | 1.971 | 0.320 |
| Histology | ||||
| Adenocarcinoma | 1.678 | 1.435 | 1.962 | <0.001 |
| Non-adenocarcinoma | 1.181 | 0.943 | 1.480 | 0.148 |
| LVI | ||||
| Absence | 1.670 | 1.442 | 1.933 | <0.001 |
| Presence | 1.207 | 0.936 | 1.556 | 0.148 |
| VPI | ||||
| Absence | 1.656 | 1.422 | 1.929 | <0.001 |
| Presence | 1.497 | 1.192 | 1.881 | 0.001 |
HR, hazard ratio; SII, systemic immune-inflammation index; RFS, recurrence-free survival; CI, confidence interval; GGO, ground-glass opacity; LVI, lymphovascular invasion; VPI, visceral pleural invasion.