Table 4. MicroRNAs associated with metastatic potential in lung cancer.
| MiRNA | Target | Ref. | |
|---|---|---|---|
| (I) Pro-metastatic miRNAs | |||
| miRNA-19 | PTEN | (60) | |
| miRNA-21 | Pdcd4 | (61) | |
| miRNA-26a | PTEN | (62) | |
| miRNA-98 | Twist | (63) | |
| MiRNA-105 | mcl-1 | (64) | |
| miRNA-126 | Snail | (65) | |
| miRNA-135b | LZTS1, Hippo pathway | (66) | |
| miRNA-137 | Transcription factor AP-2 gamma (TFAP2C) | (67) | |
| miRNA-150 | FOXO4 | (68) | |
| miRNA-191 | HIF-2α | – | |
| miRNA-196a | HOXA5 | (69) | |
| miRNA-205 | Integrin α5 | (70) | |
| miRNA-216 | – | (71) | |
| miRNA-221 | PTEN, TIMP3 | (72) | |
| miRNA-222 | PTEN, TIMP3 | (72) | |
| miRNA-328 | PRKCA | (73) | |
| miRNA-346 | Snail | (74) | |
| miRNA-455-5p | SOCO3 | (75) | |
| miRNA-506 | – | (71) | |
| miRNA-544a | Cadherin 1 | (76) | |
| miRNA-590-3p | OLFM4 | (77) | |
| miRNA-664 | AKT | (78) | |
| (II) Anti-metastatic miRNAs | |||
| miRNA-1 | Slug | (79) | |
| miRNA-22 | Snail | (80) | |
| miRNA-30a | BCL11A | (81) | |
| miRNA-33a | Twist | (82) | |
| miRNA-33b | Zeb1 | (83) | |
| miRNA-34a | Zeb1 | (84) | |
| miRNA-92b | Twist | (85) | |
| miRNA-98 | Twist | – | |
| miRNA-101 | Zeb1 | (86) | |
| miRNA-124 | Zeb1 | (87) | |
| miRNA-126 | Snail | (88) | |
| miRNA-127-3p | – | (24) | |
| miRNA-127-5p | – | (24,56) | |
| miRNA-128 | VEGF-C | (89) | |
| miRNA-132 | Zeb2 | (90) | |
| miRNA-133a-3p | – | (91) | |
| miRNA-135a | – | (24) | |
| miRNA-136 | Smad2/3 | (92) | |
| miRNA-138 | Zeb2 | (93) | |
| miRNA-144 | Zeb1 | (94) | |
| miRNA-145 | Zeb2 | (95) | |
| miRNA-148a | ROCK1 | (96) | |
| miRNA-148b | ROCK1 | (97) | |
| miRNA-154 | Zeb2 | (98) | |
| miRNA-155-5p | Zeb2 | (99) | |
| miRNA-181b | – | (100) | |
| miRNA-183 | MTA1 | (101) | |
| miRNA-191 | HIF-2α | (102) | |
| miRNA-195 | MYB | (103) | |
| miRNA-199-5p | Zeb1 | (104) | |
| miRNA-199b | Zeb1 | (105) | |
| miRNA-200s | Zeb1 | (106) | |
| miRNA-205-5p | Smad4 | (107) | |
| miRNA-206 | Met | (108) | |
| miRNA-215 | Zeb2 | (109) | |
| miRNA-216a | Zeb1 | (110) | |
| miRNA-218 | Zeb2 | (111) | |
| miRNA-296-3p | – | (24) | |
| miRNA-298 | – | (24) | |
| miRNA-299-3p | (24) | ||
| miRNA-302b-3p | GCNT3 | (112) | |
| miRNA-328-3p | γ-H2AX | (113) | |
| miRNA-412 | – | (24) | |
| miRNA-431 | – | (71) | |
| miRNA-329 | – | (24,71) | |
| miRNA-330-5p | – | (24) | |
| miRNA-361-3p | SH2B1 | (114) | |
| miRNA-369-3p | – | (24,56) | |
| miRNA-380 | – | (24) | |
| miRNA-381 | Twist | (115) | |
| miRNA-388-3p | – | – | |
| miRNA-448 | DCLK1 | (116) | |
| miRNA-452 | BMI1 | (117) | |
| miRNA-453 | – | – | |
| miRNA-455-3p | Zeb1 | (118) | |
| miRNA-485-3p | – | (71) | |
| miRNA-455-3p | Zeb1 | (118) | |
| miRNA-485-5p | IGF2BP2 | (119) | |
| miRNA-489 | SUZ12 | – | |
| miRNA-491-5p | IGF2BP1 | (120) | |
| miRNA-497 | MTDH | (121) | |
| miRNA-502-5p | – | (24) | |
| miRNA-506-3p | COTL1 | (122) | |
| miRNA-520a-3p | Rad22A | (123) | |
| miRNA-520g | – | (24) | |
| miRNA-541 | – | (24) | |
| miRNA-576-5p | – | (24) | |
| miRNA-590-5p | ADAM9 | (124) | |
| miRNA-598 | Zeb2 | (125) | |
| miRNA-654-5p | – | (24,71) | |
| miRNA-655 | – | (56,71) | |
| miRNA-876-5p | BMP-4 | (90) | |
| miRNA-887 | – | (71) | |
| miRNA-891 | – | (71) | |
| miRNA-1199-5p | Zeb1 | – | |
| miRNA-1260b | PTPRK | (126) | |
| miRNA-Let-7family | N-RAS, K-RAS, MYC HMGA2, ERCC6 and MAP3K3 | (127) | |