FIGURE 2.

Suggested pathways of cisplatin trafficking in the cochlea. The major entry route for cisplatin entry into the cochlea is via the blood-strial barrier into the stria vascularis, and clearance into the endolymph from the stria vascularis prior to entry into hair cells across their apical membrane. Reproduced with modifications from Kros and Steyger (2018) with permission of Cold Spring Harbor Laboratory Press. OCT2, Organic cation transporter; CTR1, Copper transporter 1; TMC1, Transmembrane channel-like protein 1.