Fig. 12.

Parametric empirical Bayes and Bayesian model reduction modelling of slowly changing synaptic parameters. The regressors of the between-epoch GLM comprise the frequency content in the signal (left hand side of the figure). The right side of the figure shows the GLM parameters (top row) and the reduced parameters after Bayesian model reduction (bottom row). The model reduction with this design matrix shows that inhibition and deep pyramidal cells are likely to explain the seizures at the different frequencies. ${\mathit{G}}_1$, ${\mathit{G}}_2$, ${\mathit{G}}_3$ and ${\mathit{G}}_4$ are self-inhibition parameters of excitatory, superficial pyramidal, inhibitory, and deep pyramidal cells, respectively. ${\mathit{T}}_1$, ${\mathit{T}}_2$, ${\mathit{T}}_3$ and ${\mathit{T}}_4$ are the time constant of excitatory, superficial pyramidal, inhibitory, and deep pyramidal cells, respectively.