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. 2021 Jul 26;9:685363. doi: 10.3389/fcell.2021.685363

FIGURE 6.

FIGURE 6

Schematic Diagram. Decreased expression of SETDB1 was found within 6 h after LPS treatment and short-term reduction of SETDB1 didn’t lead to DNA damage. CWA treatment significantly restores the decreased expression of SETDB1, thus exhibiting beneficial regulation on genome stability and preventing DNA damage. Stabilized genome enables ISCs to survive under infection conditions and promotes regeneration.