Table 3.
Techniques | Type | Advantages | Limitations | References |
---|---|---|---|---|
FS | Spectroscopic | Good signal–noise ratio, an abundant fluorophore | Autofluorescence, limited to the samples exhibiting fluoresce | [20], [59], [60], [176], [177] |
THzS | Spectroscopic | Use low energy and lower ionizing energy, Can generate frequency-domain and time-domain data from physical properties and chemical structure of the sample | Cannot penetrate in water and metals, scattering effect for irregular samples is also a weakness in THzS | |
NIRS | Spectroscopic | The cost-effective tool can conduct qualitative and quantitative detections | Difficult to analyze samples containing water, can generate spectral data only | |
HIS | Spectral imaging | provide spectral and spatial data, accurately differentiate the similar components of the sample even with similar color, can detect trace elements efficiently | Abundant redundant data, data processing needs a lot of time, adaptability of chemometric methods is another problem in HSI | |
RS | Spectroscopic | No interference to water, provide rich molecular Raman signatures | Weak Raman scattering cost-ineffective | |
SERS | Spectroscopic | An ultra-sensitive and specific tool, Direct/minor sample preparation needed, No interference to water and glass | Unstable hotspot regions in substrates, Sensitivity depends on the characteristics of employed nanoparticles |
Note: FS = fluorescence spectroscopy, THzS = terahertz spectroscopy, NIRS = near infrared spectroscopy, HSI = hyper spectral imaging, RS = Raman spectroscopy, SERS = surface enhanced Raman spectroscopy.